Tryptophan depletion in SSRI-recovered depressed outpatients
نویسندگان
چکیده
منابع مشابه
Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms.
BACKGROUND Acute tryptophan depletion can induce a transient reappearance of depressive symptoms in recovered depressed patients. The neurochemical mechanism is thought to be impairment of brain serotonin neurotransmission, but the neuropsychologic mechanisms underlying the effect are unclear. METHODS To assess whether low-dose tryptophan depletion can tease out the psychological mechanisms s...
متن کاملEffects of tryptophan depletion in drug-free depressed patients who responded to total sleep deprivation.
BACKGROUND There is some evidence that sleep deprivation (SD) might exert its antidepressant properties by involving serotonergic mechanisms. We investigated the effects of short-term tryptophan depletion (TD) on depressed patients who responded to a single night of total SD. METHODS Drug-free depressed inpatients (n = 30) were randomly assigned to either TD or sham depletion. Tryptophan depl...
متن کاملEmotional processing as a predictor of symptom change: an acute tryptophan depletion study in depressed patients.
Acute tryptophan depletion (ATD) in currently depressed patients has no immediate effect on symptoms, but leads to transient symptom improvement or worsening the next day. In view of recent findings concerning the cognitive effects of serotonin manipulations, we used ATD in fourteen depressed patients to investigate whether cognitive effects following ATD predict symptom changes. We found that ...
متن کاملPerceptions of Depression among Never-Depressed and Recovered-Depressed People1
We assessed perceptions of the impact of depression among two groups of currently nondepressed adults (Beck Depression Inventory score 9). The recovered-depressed (RD) participants (n 25) had a history of major depressive disorder but had been recovered for at least 2 months since the most recent depressive episode. Neverdepressed (ND) participants (n 25) had no history of major depressive diso...
متن کاملTryptophan depletion in addictive behaviours.
We read with interest the article by Cox et al 1 and the insightful editorial by Nutt 2 and applaud both the research staff and the patients involved in this important study in view of the ethical issues and challenges in their work. They provide supportive evidence that low serotonin activity can increase dopaminergic responses to cocaine in humans, suggesting a possible mechanism specific to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2001
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s002130000669